Structural Characterization and Anti-infective Activity of 9,10-Seco-29-norcycloartane Glycosides Isolated from the Flowers of the Peruvian Medicinal Plant Cordia lutea

  • J Nat Prod. 2019 Dec 27;82(12):3233-3241. doi: 10.1021/acs.jnatprod.9b00149.
Inés Castro  1  2 ,  Nicolas Fabre  1 ,  Sandra Bourgeade-Delmas  1 ,  Nathalie Saffon  3 ,  Chloé Gandini  1  2 ,  Michel Sauvain  1  2 ,  Denis Castillo  2 ,  Geneviève Bourdy  1 ,  Valérie Jullian  1  2
Affiliations
  • 1. UMR 152 PharmaDev , Université de Toulouse, IRD, UPS , Toulouse 31062 , France.
  • 2. Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía , Universidad Peruana Cayetano Heredia, Lima 15102 , Peru.
  • 3. Institut de Chimie de Toulouse, ICT FR 2599 , Université Paul Sabatier-Toulouse III , Toulouse 31062 , Cedex 9, France.
PMID: 31800248 DOI: 10.1021/acs.jnatprod.9b00149
Abstract

Six new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated.