Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

  • Nat Prod Res. 2021 Oct;35(20):3360-3369. doi: 10.1080/14786419.2019.1700247.
Nguyen Thi Mai  1 ,  Vu Van Doan  2 ,  Hoang Thi Tuyet Lan  1 ,  Bui Thi Mai Anh  1 ,  Nguyen Huy Hoang  2 ,  Bui Huu Tai  2  3 ,  Nguyen Xuan Nhiem  2  3 ,  Pham Hai Yen  2 ,  Seon Ju Park  4 ,  Yohan Seo  4 ,  Wan Namkung  4 ,  Seung Hyun Kim  4 ,  Phan Van Kiem  2  3
Affiliations
  • 1. University of Transport and Communications, Ha Noi, Vietnam.
  • 2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
  • 3. Graduate University of Science and Technology, VAST, Hanoi, Vietnam.
  • 4. College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, Korea.
PMID: 31829042 DOI: 10.1080/14786419.2019.1700247
Abstract

Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1-6) and five Lignans (7-11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new Lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (Prostate Cancer) and MCF7 (Breast Cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.

Keywords
Schisandra sphenanthera; Schisandraceae; schisandrathera A; schisandrathera B; schisandrathera C; schisandrathera D.
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