Prenylated p-Terphenyls from a Mangrove Endophytic Fungus, Aspergillus candidus LDJ-5

  • J Nat Prod. 2020 Jan 24;83(1):8-13. doi: 10.1021/acs.jnatprod.9b00004.
Guoliang Zhou  1 ,  Xiaohui Chen  1 ,  Xiaomin Zhang  1 ,  Qian Che  1 ,  Guojian Zhang  1  2 ,  Tianjiao Zhu  1 ,  Qianqun Gu  1 ,  Dehai Li  1  2  3
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , People's Republic of China.
  • 2. Laboratory for Marine Drugs and Bioproducts , Pilot National Laboratory for Marine Science and Technology , Qingdao 266237 , People's Republic of China.
  • 3. Open Studio for Druggability Research of Marine Natural Products , Pilot National Laboratory for Marine Science and Technology , Qingdao 266237 , People's Republic of China.
PMID: 31904949 DOI: 10.1021/acs.jnatprod.9b00004
Abstract

Nine previously undescribed prenylated p-terphenyls, prenylterphenyllins F-J (1, 2, 4-6) and prenylcandidusins D-G (3, 7-9), were isolated from an endophytic fungus, Aspergillus candidus LDJ-5. Their structures were determined from NMR and MS data. Differing from previously reported p-terphenyls, compound 3 represents a rare 6,5,6,6-fused ring system. Compounds 4-6 are antimicrobial, and compounds 1, 4, 6, and 9 are cytotoxic.