RP11-874J12.4 promotes oral squamous cell carcinoma tumorigenesis via the miR-19a-5p/EBF1 axis

  • J Oral Pathol Med. 2020 Aug;49(7):645-654. doi: 10.1111/jop.13000.
Guo-Min Liu  1  2 ,  Tian-Cheng Lu  2  3 ,  Mao-Lei Sun  2  4 ,  Xuan Ji  2  4 ,  Yi-An Zhao  2  4 ,  Wen-Yuan Jia  1  2 ,  Yun-Gang Luo  2  4
Affiliations
  • 1. Department of Orthopedics, The Second Hospital of Jilin University, Changchun, China.
  • 2. Jilin Provincial Changbai Mountain Medicine Anti-Cancer Engineering Center, The Second Hospital of Jilin University, Changchun, China.
  • 3. Life Sciences College, Jilin Agricultural University, Changchun, China.
  • 4. Department of Stomatology, The Second Hospital of Jilin University, Changchun, China.
PMID: 32004389 DOI: 10.1111/jop.13000
Abstract

Background: Oral Squamous Cell Carcinoma (OSCC) ranks as the fifth most frequent Cancer worldwide, and the recurrence and migration of OSCC still pose large threats to patients. Long non-coding RNAs (lncRNAs) have recently emerged as crucial players in Cancer development, and it is of great significance to understand the regulatory nexus of lncRNAs in OSCC.

Methods: Here, we identified a novel lncRNA, RP11-874J12.4, which is ectopically expressed in OSCC and facilitates OSCC.

Results: RP11-874J12.4 directly binds to and regulates miR-19a-5p. Interestingly, RP11-874J12.4 and miR-19a-5p form a negative regulatory loop that inhibits the expression of miR-19a-5p in OSCC. The expression of an oncogenic transcription factor, EBF1, is unleashed in OSCC due to the low expression of miR-19a-5p, which promotes the growth and migration of OSCC.

Conclusion: Our data illustrate a regulatory axis of RP11-874J12.4/miR-19a-5P/EBF1 and an inhibitory loop with RP11-874J12.4 and miR-19a-5p. These data provide insights into the tumorigenesis of OSCC and the novel drug targets for OSCC.

Keywords
EBF1; OSCC; RP11-874J12.4; lncRNA; miR-19a-5p.
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