In Vivo Anti-diarrheal Activity of Methanolic Extract of Streblus asper Leaves Stimulating the Na+/K+-ATPase in Swiss Albino Rats

  • Indian J Clin Biochem. 2020 Jan;35(1):72-79. doi: 10.1007/s12291-018-0781-7.
Md Shahed-Al-Mahmud  1  2 ,  Md Jalal Ahmed Shawon  2 ,  Tariqul Islam  3 ,  Md Mahmudur Rahman  3 ,  Md Rashidur Rahman  2  4
Affiliations
  • 1. 1Present Address: Department of Microbiology and Immunology, School of Medicine, Tzu Chi University, No. 701, Sec. 3, Zhongyang Rd., Hualien, 97004 Taiwan.
  • 2. 2Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka, 1217 Bangladesh.
  • 3. 3Department of Pharmacy, East West University, Plot No. A/2 Jahurul Islam City Gate, Aftab Nagar, Dhaka, 1212 Bangladesh.
  • 4. 4Department of Pharmacy, Faculty of Biological Science and Technology, Jessore University of Science and Technology, Jessore, 7408 Bangladesh.
PMID: 32071498 DOI: 10.1007/s12291-018-0781-7
Abstract

Streblus asper Lour., traditionally used for anti-diarrheal effects as like dysentery and diarrhea. The present study aims to prove the anti-diarrheal activities of methanolic extract of leaves of S. asper in animal models. The anti-diarrheal activity was evaluated using castor oil-induced diarrhea and magnesium sulphate-induced diarrhea models whereas anti-motility activities were investigated using gastrointestinal transit test examined in animal models. In castor oil-induced diarrhea model, methanolic extract of S. asper (MESA) at the doses of 100, 200, and 400 mg/kg produced statistically significant (P < 0.001) decreased the number of diarrheal feces of rats against castor oil-induced diarrhea as well as magnesium sulphate-induced diarrhea model also showed the same manner. In gastrointestinal transit test, delayed gastric emptying time decreased significantly (P < 0.001), the propulsion of charcoal meal in the gastrointestinal tract which also showed a dose-dependent manner in rats. The recent study indicates that MESA possesses anti-diarrheal property. The findings represent a rational explanation for its use in traditional medicine for the management of diarrhea management.

Keywords
Anti-diarrheal; Anti-motility; Anti-secretory; Castor oil; Streblus asper Lour..
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