New prenylflavonol glycosides with xanthine oxidase inhibitory activity from the leaves of Cyclocarya paliurus

  • Bioorg Chem. 2020 Aug;101:104018. doi: 10.1016/j.bioorg.2020.104018.
Zi-Jun Ye  1 ,  Xiao-Ai He  1 ,  Jian-Ping Wu  2 ,  Jing Li  2 ,  Xi-Wen Chang  2 ,  Jie Tan  2 ,  Wen-Yan Lv  2 ,  Hui Zhu  2 ,  Hui-Hui Sun  2 ,  Wen-Xuan Wang  2 ,  Zu-Hui Chen  3 ,  Gang-Zhi Zhu  1 ,  Kang-Ping Xu  4
Affiliations
  • 1. Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou 570100, PR China.
  • 2. Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • 3. Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China; Hunan Heran Biotechnology Development Company, 410013 Changsha, PR China.
  • 4. Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China. Electronic address: [email protected].
PMID: 32629277 DOI: 10.1016/j.bioorg.2020.104018
Abstract

Eight new prenylflavonol glycosides (1-8), along with five known analogues (9-13) were isolated from the n-butanol extract of the dried leaves of Cyclocarya paliurus (family Juglandaceae) for the first time. The structures of these compounds were characterized by comprehensive analysis of 1D, 2D NMR, HRESIMS, UV data and acid hydrolysis. In bioassay, all these thirteen prenylflavonol glycosides exhibited inhibitory effects on Xanthine Oxidase (XOD) activity. Especially compounds 2 and 7, showed outstanding IC50 values of 31.81 ± 2.20 and 29.71 ± 3.69 μM, respectively.

Keywords
Cyclocarya paliurus; Prenylflavonol glycosides; Xanthine oxidase inhibitory activities.
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