Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells

  • Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1339-1357. doi: 10.1161/ATVBAHA.120.315206.
Andrew M Cobb  1 ,  Syabira Yusoff  1 ,  Robert Hayward  1 ,  Sadia Ahmad  1 ,  Mengxi Sun  1 ,  Anja Verhulst  2 ,  Patrick C D'Haese  2 ,  Catherine M Shanahan  1
Affiliations
  • 1. BHF Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, The James Black Centre, United Kingdom (A.M.C., S.Y., R.H., S.A., M.S., C.M.S.).
  • 2. Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium (A.V., P.C.D.).
PMID: 33356386 DOI: 10.1161/ATVBAHA.120.315206
Abstract

[Figure: see text].

Keywords
DNA damage; aging; apoptosis; poly ADP ribosylation; vascular calcification.