Progress in the total synthesis of inthomycins

  • Beilstein J Org Chem. 2021 Jan 7:17:58-82. doi: 10.3762/bjoc.17.7.
Bidyut Kumar Senapati  1
Affiliations
  • 1. Department of Chemistry, Prabhat Kumar College, Contai, 721404, India, Tel.: +91 8145207480.
PMID: 33488832 DOI: 10.3762/bjoc.17.7
Abstract

The inthomycin family of Antibiotics, isolated from Streptomyces strains, are interesting molecules for synthesis due to their characteristic common oxazole polyene chiral allylic β-hydroxycarbonyl fragments and significant biological activities. The full structural motif of the inthomycins is found in several more complex natural products including the oxazolomycins, 16-methyloxazolomycin, curromycins A and B, and KSM-2690. This review summarises the application of various efforts towards the synthesis of inthomycins and their analogues systematically.

Keywords
Stille coupling; antibiotics; inthomycins; oxazololomycin; total synthesis.
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