Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease

  • Gut. 2022 Apr;71(4):842-844. doi: 10.1136/gutjnl-2021-324727.
Nicolas Hohmann  1 ,  Fabian Schröder  2 ,  Bernardo Moreira  2 ,  Haidong Teng  2 ,  Jürgen Burhenne  1 ,  Thomas Bruckner  3 ,  Sebastian Mueller  2 ,  Walter E Haefeli  #  1 ,  Helmut K Seitz  #  4
Affiliations
  • 1. Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Heidelberg, Germany.
  • 2. Department of Medicine, Krankenhaus Salem, Heidelberg, Baden-Württemberg, Germany.
  • 3. Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Baden-Württemberg, Germany.
  • 4. Krankenhaus Salem, Heidelberg, Baden-Württemberg, Germany [email protected].
  • # Contributed equally.
PMID: 33972357 DOI: 10.1136/gutjnl-2021-324727
Keywords
alcohol; alcoholic liver disease; clinical trials; cytochrome p450.
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