Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells

  • Bioengineered. 2021 Dec;12(2):10037-10048. doi: 10.1080/21655979.2021.1994737.
Changcheng Wang  1 ,  Jia Guo  1 ,  Zeng'An Wu  1
Affiliations
  • 1. Division of General Surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
PMID: 34666596 DOI: 10.1080/21655979.2021.1994737
Abstract

TNBC: triple negative breast cancer; ROS: reactive oxygen species; NAC: N-acetyl-L-cysteine; DTX: docetaxel; MAPKs: mitogen-actived protein kinases; PI3K/Akt: phosphatidylinositol 3-kinases (PI3K) /Akt; NF-Κb: the nuclear factor κB (NF-κB).

Keywords
Curdione; chemo-sensitization; docetaxel; reactive oxygen species (ROS); triple-negative breast cancer (TNBC).
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