Myocardial Fatigue at a Glance

  • Curr Heart Fail Rep. 2023 Jun;20(3):191-193. doi: 10.1007/s11897-023-00603-3.
Patrick Tran  1  2 ,  Prithwish Banerjee  3  4  5
Affiliations
  • 1. University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK. [email protected].
  • 2. Centre for Sport, Exercise, Life Sciences, Faculty of Health and Life Sciences, Coventry University, Alison Gingell Building, Coventry, CV1 2DS, UK. [email protected].
  • 3. University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK.
  • 4. Centre for Sport, Exercise, Life Sciences, Faculty of Health and Life Sciences, Coventry University, Alison Gingell Building, Coventry, CV1 2DS, UK.
  • 5. Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
PMID: 37133679 DOI: 10.1007/s11897-023-00603-3
Abstract

Expanding on the modern lexicon of Heart Failure (HF), the novel mechano-energetic concept of myocardial fatigue describes a transiently energy-depleted myocardium with impaired contractility and relaxation in the face of adverse haemodynamic load. It encompasses established concepts of ventricular-arterial decoupling, deranged cardiac energetics and impaired myocardial efficiency, offering an alternative explanation for functional causes of HF.