Optimization and applications of an in vivo bioluminescence imaging model of influenza A virus infections

  • Virol Sin. 2023 Aug;38(4):631-634. doi: 10.1016/j.virs.2023.04.007.
Xiaojing Lin  1 ,  Murong Zhu  1 ,  Xiujuan Zhao  1 ,  Longlong Si  2 ,  Meiyue Dong  1 ,  Varada Anirudhan  3 ,  Qinghua Cui  4 ,  Lijun Rong  5 ,  Ruikun Du  6
Affiliations
  • 1. Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 50355, China.
  • 2. CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • 3. Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • 4. Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 50355, China; Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, 266122, China. Electronic address: [email protected].
  • 5. Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address: [email protected].
  • 6. Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 50355, China; Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, 266122, China. Electronic address: [email protected].
PMID: 37141991 DOI: 10.1016/j.virs.2023.04.007
Abstract

  1. •

    The in vivo BLI model of IAV infections can simplify the determination of viral load in living Animals.

  2. •

    The in vivo BLI model of IAV infections allow longitudinal measurements of virus Infection/spread in living Animals.

  3. •

    The in vivo BLI model of IAV infections improved the throughput of animal models.

  4. •

    The advanced BLI models can facilitate studies in both basic and applied virology.

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