Tumor-microenvironment responsive nano-carrier system for therapy of prostate cancer

  • J Mater Sci Mater Med. 2023 Sep 21;34(10):46. doi: 10.1007/s10856-023-06749-9.
Lujing Li  #  1 ,  Renjie Li  #  1 ,  Jiachun Li  #  2 ,  Jiyi Yao  3 ,  Qingyuan Zhang  4 ,  Qiao Ji  5 ,  Zuofeng Xu  6
Affiliations
  • 1. Department of Ultrasound, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China.
  • 2. Department of orthopedics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China.
  • 3. Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
  • 4. Department of Gastrointestinal surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China. [email protected].
  • 5. Department of Ultrasound, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China. [email protected].
  • 6. Department of Ultrasound, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China. [email protected].
  • # Contributed equally.
PMID: 37735283 DOI: 10.1007/s10856-023-06749-9
Abstract

Poor selectivity, low bioavailability and serious systemic side-effects have limited the application of traditional chemotherapy method for treatment of prostate Cancer. Stimuli-responsive drug delivery systems for chemotherapy are mainly based on the unique characteristics of tumor microenvironment. In this study, the GSH-sensitive poly-TTG-SS@DTX NPs (DTX-loaded poly-Tetraethylene glycol nanoparticles) were designed and synthesized, which were characterized with nanosized diameter (92.8 ± 2.5 nm) and negatively charged surface charge (-24.7 ± 5.56 mV). Experiments in vitro showed that poly-TTG-SS@DTX NPs had good compatibility to healthy cells and strong anti-tumor effect because of rapid and sustained drug release of DTX from poly-TTG-SS@DTX NPs under the tumor-microenvironment condition. The cellular activity remained greater than 90% when the concentration of poly-TTG-SS NPs reached as high as 100 µg/mL treated on healthy cells. The killing effect of DTX loading NPs group on C4-2 cells was stronger than that of free anti-tumor drug and free DTX combined with the blank nano-carrier (25.21% vs 19.93% vs 20.96%). In conclusion, poly-TTG-SS@DTX NPs may provide a new therapeutic strategy for the chemotherapy of prostate Cancer.

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