NOD1: a metabolic modulator

  • Front Endocrinol (Lausanne). 2025 Jan 21:15:1484829. doi: 10.3389/fendo.2024.1484829.
Ruobing Tang  1 ,  Chunguang Xie  1  2  3 ,  Xiyu Zhang  1  2  3
Affiliations
  • 1. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
  • 2. TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, China.
  • 3. Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
PMID: 39906040 DOI: 10.3389/fendo.2024.1484829
Abstract

Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular pattern recognition receptor that detects injury signals and initiates inflammatory responses and host defense. Furthermore, NOD1 serves as a metabolic mediator by influencing the metabolism of various tissues, including adipose tissue, liver, cardiovascular tissue, pancreatic β cells, adrenal glands, and bones through diverse mechanisms. It has been discovered that activated NOD1 is associated with the pathological mechanisms of certain metabolic diseases. This review presents a comprehensive summary of the impact of NOD1 on tissue-specific metabolism.

Keywords
NOD1; endocrine; immunity; inflammation; metabolism.