6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling

  • Cell Biochem Biophys. 2025 Dec;83(4):5307-5319. doi: 10.1007/s12013-025-01850-y.
Xiao Qi  1 ,  Chong Niu  1 ,  Zi-Zheng Zhang  2 ,  Meng-Ru Chen  2 ,  Feng-Ze Wang  3 ,  Hong-Rong Fei  4
Affiliations
  • 1. School of Pharmacy (Institute of Pharmaceutical Research), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
  • 2. School of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, PR China.
  • 3. Center Laboratory, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, PR China. [email protected].
  • 4. School of Pharmacy (Institute of Pharmaceutical Research), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. [email protected].
PMID: 40879881 DOI: 10.1007/s12013-025-01850-y
Keywords
6-Methoxydihydrosanguinarine; Akt; JNK; NSCLC; ROS; YAP.
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