Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats
- Arch Geschwulstforsch. 1978;48(1):1-8.
PMID: 418748
Abstract
It is shown that daily oral administration of 5--10 mg of an antidiabetic biguanide-phenformin (phenethyl-biguanide) for 2.5--5 months suppressed DMBA-induced mammary tumour development in rats considerably. Phenformin-treated rats revealed-a tendency towards a decrease in blood Insulin level (radioimmunoassay). The obtained data are regarded as additional evidence for the proposed existence of the same metabolic background of diseases of compensation, i.e. adult-onset diabetes, artherosclerosis and Cancer, and suggest studies on possible antitumour effect of phenformin in man.
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