LINC01106 Facilitates Oral Squamous Cell Carcinoma Progression by Sponging miRNA-449a and Regulating MYC Expression

  • Oral Dis. 2026 Mar 27. doi: 10.1111/odi.70289.
Jiayu Chen  1 ,  Lichao Yang  1 ,  Hao Liu  1 ,  Meijie Shen  2 ,  Jiaqing Sun  2 ,  Renjie Fu  2 ,  Yan Geng  3 ,  Shiliang Cheng  1
Affiliations
  • 1. Department of Clinical Laboratory, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong, China.
  • 2. Department of Stomatology, The Tongxiang First People's Hospital, Tongxiang, Zhejiang, China.
  • 3. The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
PMID: 41896711 DOI: 10.1111/odi.70289
Abstract

Objective: The study investigated the biological roles of LINC01106 in oral Squamous Cell Carcinoma (OSCC) progression.

Methods and methods: RT-qPCR quantified LINC01106 levels in OSCC tissues and cell lines. Cell proliferation, migration, and invasion assays evaluated its function, while luciferase reporter assays and Western blot confirmed the regulatory axis.

Results: Elevated LINC01106 expression in OSCC tissues and cell lines correlated with poor prognosis. Multivariate COX analysis identified high LINC01106 as an independent adverse prognostic factor for overall survival (OS). LINC01106 silencing suppressed proliferation, migration, and invasion of OSCC cells and reduced xenograft growth. Mechanistically, LINC01106 sponged miR-449a to up-regulate MYC; inhibition of miR-449a or MYC re-expression rescued the malignant phenotype after LINC01106 knockdown.

Conclusion: LINC01106 exerts oncogenic effects via the miR-449a/MYC axis and may serve as a therapeutic target in OSCC.

Keywords
LINC01106; LINC01106/miR‐449a/MYC axis; oral squamous cell carcinoma.
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