Compounds from Aquilaria sinensis against renal fibrosis in vitro

  • J Asian Nat Prod Res. 2026 May 21:1-9. doi: 10.1080/10286020.2026.2661019.
Yong-Yong Liao  1  2 ,  Mei Wang  2 ,  Yan-Zhi Wang  3 ,  Yong-Xian Cheng  1  2
Affiliations
  • 1. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • 2. Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Marshall Laboratory of Biomedical Engineering, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.
  • 3. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
PMID: 42166271 DOI: 10.1080/10286020.2026.2661019
Abstract

Three previously undescribed compounds (1-3), including two sesquiterpenoids (1 and 2), one 2-(2-phenylethyl) chromone (3), along with six known compounds (4-9) were isolated from the heartwood of Aquilaria sinensis (Chinese agarwood). The structures of new compounds (1-3) were established by spectroscopic methods including UV, HRESIMS, 1D, 2D NMR, and the comparison of experimental and calculated ECD data. In addition, compounds 1-3 were found to show anti-renal fibrosis activity in TGF-β1-induced NRK-52e cells. The results have demonstrated that compound 3 inhibits renal fibrosis in a dose-dependent manner.

Keywords
2-(2-phenylethyl) chromones; Aquilaria sinensis; Thymelaeaceae; anti-renal fibrosis; sesquiterpenoids.
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