Aurantimycins, new depsipeptide antibiotics from Streptomyces aurantiacus IMET 43917. Production, isolation, structure elucidation, and biological activity

  • J Antibiot (Tokyo). 1995 Feb;48(2):119-25. doi: 10.7164/antibiotics.48.119.
U Gräfe  1 ,  R Schlegel ,  M Ritzau ,  W Ihn ,  K Dornberger ,  C Stengel ,  W F Fleck ,  W Gutsche ,  A Härtl ,  E F Paulus
Affiliations
  • 1. Hans-Knöll-Institute of Natural Product Research, Jena, Germany.
PMID: 7706121 DOI: 10.7164/antibiotics.48.119
Abstract

Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide Antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field homo- and heteronuclear 2D NMR experiments, high-resolution mass spectrometry and amino acid analysis. Aurantimycins are characterized by a new side chain containing fourteen carbon atoms. They display strong activity against Gram-positive bacteria and cytotoxic effects against L-929 mouse fibroblast cells.

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