Fungal metabolites. Part 14. Novel potent immunosuppressants, mycestericins, produced by Mycelia sterilia

  • J Antibiot (Tokyo). 1994 Apr;47(4):420-33. doi: 10.7164/antibiotics.47.420.
S Sasaki  1 ,  R Hashimoto ,  M Kiuchi ,  K Inoue ,  T Ikumoto ,  R Hirose ,  K Chiba ,  Y Hoshino ,  T Okumoto ,  T Fujita
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
PMID: 8195042 DOI: 10.7164/antibiotics.47.420
Abstract

Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (= myriocin). Their structures were elucidated on the basis of spectroscopic studies and chemical evidence. The acetate of mycestericin C was identical with the acetate of 6,7-dihydromyriocin. Mycestericins suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction, with a potency similar to that of myriocin.

Products