TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity

  • J Antibiot (Tokyo). 1993 Apr;46(4):606-13. doi: 10.7164/antibiotics.46.606.
N Katayama  1 ,  S Fukusumi ,  Y Funabashi ,  T Iwahi ,  H Ono
Affiliations
  • 1. Discovery Research Laboratories II, Takeda Chemical Industries, Ltd., Osaka, Japan.
PMID: 8501003 DOI: 10.7164/antibiotics.46.606
Abstract

Two Gram-negative bacteria were found to produce the new Antibacterial antibiotics TAN-1057 A, B, C and D. The producing bacteria were characterized and designated as Flexibacter sp. PK-74 and PK-176. These Antibiotics were active against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. TAN-1057 A inhibited protein biosynthesis in Escherichia coli and S. aureus. It showed excellent protective effects against an experimental methicillin-resistant S. aureus Infection in mice.

Products