Nothramicin, a new anthracycline antibiotic from Nocardia sp. MJ896-43F17

  • J Antibiot (Tokyo). 1998 Feb;51(2):130-5. doi: 10.7164/antibiotics.51.130.
I Momose  1 ,  N Kinoshita ,  R Sawa ,  H Naganawa ,  H Iinuma ,  M Hamada ,  T Takeuchi
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 9544933 DOI: 10.7164/antibiotics.51.130
Abstract

A new Antibiotic designated nothramicin was isolated from the culture broth of Nocardia sp. MJ896-43F17 which was closely related to Nocardia brasiliensis. It was isolated by the Diaion HP-20 column chromatography, butyl acetate extraction and purified by HPLC. It inhibited the growth of mycobacteria at the concentration of 1.56 approximately 25 microg/ml. Nothramicin was revealed to be a new member of anthracycline Antibiotics by the various spectroscopies.

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