Formamicin, a novel antifungal antibiotic produced by a strain of Saccharothrix sp. I. Taxonomy, production, isolation and biological properties

  • J Antibiot (Tokyo). 1997 Nov;50(11):926-31. doi: 10.7164/antibiotics.50.926.
M Igarashi  1 ,  N Kinoshita ,  T Ikeda ,  E Nakagawa ,  M Hamada ,  T Takeuchi
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 9592565 DOI: 10.7164/antibiotics.50.926
Abstract

Formamicin, an antifungal Antibiotic, was isolated from the cultured broth of an actinomycete strain. The strain was isolated from a soil collected at Setagaya-ku, Tokyo, Japan, and identified as Saccharothrix sp. MK27-91F2. Formamicin was extracted with acetone from cultured mycelia and purified by silicagel and Sephadex LH-20 column chromatographies and CPC (Centrifugal liquid-liquid Partition Chromatography). Formamicin showed strong antimicrobial activity against phytopathogenic fungi.

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