Synthesis of (+/-)-cassumunins A and B, new curcuminoid antioxidants having protective activity of the living cell against oxidative damage

  • J Nat Prod. 1998 May;61(5):609-13. doi: 10.1021/np970555g.
T Masuda  1 ,  H Matsumura ,  Y Oyama ,  Y Takeda ,  A Jitoe ,  A Kida ,  K Hidaka
Affiliations
  • 1. Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770, Japan. [email protected]
PMID: 9599258 DOI: 10.1021/np970555g
Abstract

A chemical synthesis of cassumunins A (1) and B (2), natural curcuminoid Antioxidants, was developed. The synthesis was started from o-vanillin and after nine reaction steps resulted in 20% and 26% overall yields of 1 and 2, respectively. The synthetic cassumunins showed stronger protective activity than curcumin against oxidative cell death induced by hydrogen peroxide in a rat thymocyte system.