Reactions of 1-methylbenzimidazole derivatives with m-chloroperoxybenzoic acid

  • Bioorg Med Chem Lett. 1998 Mar 17;8(6):625-30. doi: 10.1016/s0960-894x(98)00082-1.
T Kaiya  1 ,  S Aoyama ,  K Kohda
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
PMID: 9871572 DOI: 10.1016/s0960-894x(98)00082-1
Abstract

Oxidation of seven 1-methylbenzimidazole (MBI) derivatives (with pKa's ranging from 1.6 to 6.0) was carried out with m-chloroperoxybenzoic acid and structures of the products formed were identified. (Condensed benzene moiety-hydroxylated)-2-(m-chlorobenzyloxy)-MBIs and 2-oxo-MBIs were obtained from MBIs with pKa's of more than 5.6 and about 3.3, respectively.

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