pUL89 Endonuclease-IN-1

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pUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC₅₀ value of 0.88 μM and has antiviral activitiy.

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pUL89 Endonuclease-IN-1 Chemische Struktur

CAS. Nr. : 391680-92-5

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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

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Beschreibung

pUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC₅₀ value of 0.88 μM and has antiviral activitiy^[1].

IC₅₀ & Target

IC50:0.88μM (pUL89-C)

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	CC₅₀	>100 μM Compound: 13d	Cytotoxicity against HFF cells assessed as cell viability incubated for 168 hrs by MTS-based Cell Titer assay Cytotoxicity against HFF cells assessed as cell viability incubated for 168 hrs by MTS-based Cell Titer assay	[PMID: 35377638]

In Vitro

pUL89 Endonuclease-IN-1 (compound 13d) is strongly inhibited pUL89-C with the values of IC₅₀0.88μM. pUL89 Endonuclease-IN-1 reveals excellent aqueous solubility, plasma stability, and metabolic stability in vitro ADME. pUL89 Endonuclease-IN-1 displays moderately permeability in the PAMPA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HFF cells
Concentration:	5 μM
Incubation Time:	168 h
Result:	Showed significant inhibition for HCMV at 5 μM.

Molekulargewicht

252.25

Formel

C₁₀H₈N₂O₄S

CAS. Nr.

391680-92-5

SMILES

COC(C1=C(C(O)=NC(C2=CC=CS2)=N1)O)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Tianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65(7):5830-5849. [Content Brief]

[2]. ianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65(7):5830-5849. [Content Brief]