RBWH15

RBWH15 (0.375-18 μM, >200 μM; 18-24 h) potently inhibits the growth of multiple Gram-positive and Gram-negative ESKAPE pathogens, including methicillin-resistant S. aureus ATCC43300, with MIC values ranging from 1.5 μM to 18 μM, and shows no activity against E. faecalis ATCC19433 at tested concentrations^[1].
RBWH15 (2.3-36 μM, 9-144 μM) permeabilizes the outer membranes of S. aureus ATCC25923 and P. aeruginosa PAO1 in a concentration-dependent manner^[1].
RBWH15 (2.3-36 μM, 9-144 μM) disrupts the inner membranes of S. aureus ATCC25923 and P. aeruginosa PAO1 in a concentration-dependent manner, leading to increased PI uptake by membrane-compromised bacteria^[1].
RBWH15 (2.3-36 μM, 9-144 μM; 90 min, 24 h) eradicates preformed biofilms of S. aureus ATCC25923 and P. aeruginosa PAO1 in a concentration-dependent manner^[1].
RBWH15 (2.5-10 μM; 24-48 h) promotes migration of L929 mouse fibroblasts, accelerating in vitro wound closure over 48 h of incubation^[1].
RBWH15 (30 min-24 h) exhibits moderate stability in human plasma, with ~35-44% of the peptide remaining intact after 24 h of incubation at 37 °C^[1].
RBWH15 (30-60 μM; 1-3 h) is non-hemolytic against murine and human RBCs at concentrations up to 60 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.