ABCC2 Protein, Human (HEK293)
ABCC2 Protein, Human (HEK293) is the recombinant human-derived ABCC2, expressed by HEK293, with tag free labeled tag.
- Species: Human
- Source: HEK293
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Biological Activity
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Product Properties
- Documentation
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Biological Activity
ABCC2 Protein, Human (HEK293) is the recombinant human-derived ABCC2, expressed by HEK293, with tag free labeled tag.
ABCC2 is an ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates, including drugs, toxicants, and endogenous compounds. It transports a wide variety of conjugated organic anions, such as sulfate-, glucuronide-, and glutathione (GSH)-conjugates of endo- and xenobiotic substrates (by similar). ABCC2 mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules, playing a key role in bilirubin detoxification (by similar). It also facilitates the excretion of other glucuronide conjugates, such as 17β-estradiol 17-glucosiduronic acid and leukotriene C4, as well as sulfated bile salts like taurolithocholate sulfate (by similar). Additionally, ABCC2 transports various anticancer drugs (e.g., anthracyclines, vinca alkaloids, and methotrexate) and HIV drugs (e.g., protease inhibitors), conferring resistance to multiple anticancer agents, including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide, and vincristine.
Technical Parameters
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Species Human
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Source HEK293
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Tag Tag Free
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Accession
Q92887 (M1-F1545)
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Gene ID1244
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Protein Length
Full Length
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Synonyms
ABCC2; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2; Prev. CMOAT; Multidrug Resistance-Associated Protein 2; CMRP; Canalicular Multidrug Resistance Protein; MRP2; CMOAT1; Canalicular Multispecific Organic Anion Transporter 1; ABC30; DJS; ATP Bi
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AA Sequence
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF
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Predicted Molecular Mass
174.9 kDa
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Glycosylation
Yes
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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