ACE2 Protein, Paguma larvata (HEK293, His)
ACE2 is an important carboxypeptidase in the renin-angiotensin system, converting angiotensin I to anti-hypertrophic angiotensin 1-9 and vasoconstrictor angiotensin II to vasodilator angiotensin 1-7, thereby regulating cardiovascular homeostasis. It can remove the C-terminal residues of vasoactive peptides and cleave a variety of biological peptides. ACE2 Protein, Paguma larvata (HEK293, His) is the recombinant ACE2 protein, expressed by HEK293 , with N-His labeled tag. The total length of ACE2 Protein, Paguma larvata (HEK293, His) is 723 a.a., with molecular weight of 90-115 kDa.
- Species: Others
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
ACE2 is an important carboxypeptidase in the renin-angiotensin system, converting angiotensin I to anti-hypertrophic angiotensin 1-9 and vasoconstrictor angiotensin II to vasodilator angiotensin 1-7, thereby regulating cardiovascular homeostasis. It can remove the C-terminal residues of vasoactive peptides and cleave a variety of biological peptides. ACE2 Protein, Paguma larvata (HEK293, His) is the recombinant ACE2 protein, expressed by HEK293 , with N-His labeled tag. The total length of ACE2 Protein, Paguma larvata (HEK293, His) is 723 a.a., with molecular weight of 90-115 kDa.
Background
ACE2, an essential counter-regulatory carboxypeptidase in the renin-angiotensin hormone system, emerges as a pivotal regulator of blood volume, systemic vascular resistance, and cardiovascular homeostasis. Its multifaceted enzymatic activities include the conversion of angiotensin I to angiotensin 1-9, an anti-hypertrophic peptide in cardiomyocytes, and angiotensin II to angiotensin 1-7, a vasodilator with anti-proliferative properties that counterbalance the vasoconstrictor effects of angiotensin II. ACE2's repertoire extends to removing the C-terminal residue from vasoactive peptides such as neurotensin, kinetensin, and des-Arg bradykinin, while not affecting bradykinin. Additionally, ACE2 cleaves diverse biological peptides like apelins, casomorphins, and dynorphin A. Beyond its enzymatic roles, ACE2 assumes importance in amino acid transport, acting as a binding partner for the amino acid transporter SLC6A19 in the intestine, where it regulates trafficking, surface expression, and catalytic activity. In the context of microbial infection, ACE2 serves as a receptor for the human coronavirus SARS.
Technical Parameters
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Species Others
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Source HEK293
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Tag N-His
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Accession
Q56NL1 (Q18-T740)
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Gene ID/
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Molecular Construction
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N-term
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His
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ACE2 (Q18-T740)
Accession # Q56NL1 -
C-term
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Protein Length
Extracellular Domain
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Synonyms
ACE2; Angiotensin I Converting Enzyme 2; Angiotensin Converting Enzyme 2; Angiotensin-Converting Enzyme 2; ACEH; ACE-Related Carboxypeptidase; Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2; Metalloprotease MPROT15; Angiotensin-Converting Enzy
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AA Sequence
QSTTEELAKTFLETFNYEAQELSYQSSVASWNYNTNITDENAKNMNEAGAKWSAYYEEQSKLAQTYPLAEIQDAKIKRQLQALQQSGSSVLSADKSQRLNTILNAMSTIYSTGKACNPNNPQECLLLEPGLDNIMENSKDYNERLWAWEGWRAEVGKQLRPLYEEYVALKNEMARANNYEDYGDYWRGDYEEEWTGGYNYSRNQLIQDVEDTFEQIKPLYQHLHAYVRAKLMDTYPSRISRTGCLPAHLLGDMWGRFWTNLYPLTVPFGQKPNIDVTDAMVNQNWDARRIFKEAEKFFVSVGLPNMTQGFWENSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPNHLKTIGLLSPAFSEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGAIPKEQWMQKWWEMKRNIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTRTIYQFQFQEALCQIAKHEGPLHKCDISNSTEAGKKLLEMLSLGRSEPWTLALERVVGAKNMNVTPLLNYFEPLFTWLKEQNRNSFVGWDTDWRPYSDQSIKVRISLKSALGEKAYEWNDNEMYLFRSSIAYAMREYFSKVKNQTIPFVEDNVWVSDLKPRISFNFFVTFSNNVSDVIPRSEVEDAIRMSRSRINDAFRLDDNSLEFLGIEPTLSPPYRPPVT
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Predicted Molecular Mass
85.7 kDa
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Molecular Weight
Approximately 90-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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