Bcl-2-like protein 11 Protein, Human (His)
Based on 1 Customer Validation
Bcl-2-like protein 11 (BCL2L11), despite its classification, does not interact with humanin. This unique feature distinguishes BCL2L11 from expected protein-protein interactions typically associated with Bcl-2 family members. Bcl-2-like protein 11 Protein, Human (His) is the recombinant human-derived Bcl-2-like protein 11 protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Bcl-2-like protein 11 (BCL2L11), despite its classification, does not interact with humanin. This unique feature distinguishes BCL2L11 from expected protein-protein interactions typically associated with Bcl-2 family members. Bcl-2-like protein 11 Protein, Human (His) is the recombinant human-derived Bcl-2-like protein 11 protein, expressed by E. coli , with N-6*His labeled tag.
Background
Bcl-2-like protein 11 (BCL2L11), also known as BIM, engages in critical protein interactions that modulate its cellular functions. Phosphorylated BCL2L11 interacts with USP27X, leading to BCL2L11 deubiquitination and subsequent stabilization. This interaction suggests a regulatory mechanism for BCL2L11 levels, influencing its role in apoptotic pathways. Additionally, BCL2L11 interacts with humanin, and this interaction serves a protective function by preventing BIM-induced apoptosis. The intricate interplay between BCL2L11, USP27X, and humanin highlights the complexity of apoptotic regulation and underscores the importance of post-translational modifications in modulating the stability and activity of BCL2L11. Further research is necessary to fully elucidate the molecular mechanisms and physiological implications of these interactions in cellular processes and potential implications for therapeutic interventions.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
O43521-2/NP_006529.1 (A2-R120)
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Molecular Construction
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N-term
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6*His
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Bcl-2-like (A2-R120)
Accession # O43521-2/NP_006529.1 -
C-term
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Protein Length
Full Length of Isoform-2
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Synonyms
BCL2L11; BimS; BCL2 Like 11; Bcl-2 Interacting Mediator Of Cell Death; BIM; Bcl2-Interacting Mediator Of Cell Death; BOD; Bcl-2-Related Ovarian Death Agonist; BCL2-Like 11 (Apoptosis Facilitator); Bcl-2 Interacting Protein Bim; Bcl-2-Like Protein 11; Bcl2-L-11; BimEL; BAM; BimL
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Predicted Molecular Mass
15 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Lyophilized from a 0.22 μm filtered solution of 50 mM Tris, 10% Glycerol, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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