C-Reactive Protein, Cynomolgus (HEK293, His)
Reactive protein (CRP) performs multiple functions of host defense, including promoting agglutination, bacterial capsule swelling, phagocytosis, and complement fixation. These activities are promoted by its calcium-dependent binding to phosphocholine, suggesting its role in orchestrating immune responses against pathogens. C-Reactive Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C-Reactive protein, expressed by HEK293 , with C-His labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
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Biological Activity
Description
Reactive protein (CRP) performs multiple functions of host defense, including promoting agglutination, bacterial capsule swelling, phagocytosis, and complement fixation. These activities are promoted by its calcium-dependent binding to phosphocholine, suggesting its role in orchestrating immune responses against pathogens. C-Reactive Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C-Reactive protein, expressed by HEK293 , with C-His labeled tag.
Background
C-Reactive Protein (CRP) plays a multifaceted role in host defense, demonstrating several functions essential for immune responses. CRP promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation by binding to phosphorylcholine in a calcium-dependent manner. Additionally, CRP exhibits the ability to interact with DNA and histones, suggesting a potential role in scavenging nuclear material released from damaged circulating cells. These diverse functions underscore CRP's involvement in various aspects of the immune system, contributing to both innate and adaptive immune responses, and highlight its significance as a key player in host defense mechanisms.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-8*His
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Accession
XP_045255377.1 (Q19-S224)
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Molecular Construction
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N-term
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C-Reactive (Q19-S224)
Accession # XP_045255377.1 -
8*His
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C-term
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Protein Length
Full Length of Pentraxin family member Chain
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Synonyms
CRP; C-Reactive Protein, Pentraxin-Related; C-Reactive Protein; Pentraxin 1; PTX1
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AA Sequence
QTDMSMKAFVFPKESDNSYVTLKARLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQNNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRARKSLKRGYTVGEDASIILGQEQDSFGGSFETQQSLVGDIGNVNMWDFVLSPDEISTVYRGGTFSPSVLYWRALKYEVQGEVFIKPQLWS
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Predicted Molecular Mass
24.3 kDa
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Molecular Weight
Approximately 25-30 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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