Cadherin-1/CD324 Protein, Human (Biotinylated, HEK293, His, Avi)

The Cadherin-1/CD324 protein is a calcium-dependent cell adhesion protein that interacts with homology in junctional cells to facilitate cell type sorting. CDH1 is involved in regulating intercellular adhesion, mobility, and epithelial cell proliferation. Cadherin-1/CD324 Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived Cadherin-1/CD324 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

Cadherin-1 (CD324) is a calcium-dependent cell adhesion protein known for its preference to interact homophilically with itself in adjacent cells, thereby contributing to the sorting of heterogeneous cell types. CDH1, a member of the cadherin family, plays a crucial role in regulating cell-cell adhesions, influencing the mobility and proliferation of epithelial cells. Notably, CDH1 exhibits a potent role as an invasive suppressor and serves as a ligand for integrin alpha-E/beta-7E, impacting non-amyloidogenic degradation of Abeta precursors. Moreover, CDH1 demonstrates a robust inhibitory effect on the production of APP C99 and C83, further emphasizing its multifaceted involvement in cellular processes and its potential implications in pathological contexts.

Human

HEK293

C-Avi;C-8*His

P12830-1 (D155-A709)

999

Extracellular Domain

Biotin

DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPA

Approximately 75-90 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.