CBX5 Protein, Human (His, Myc)
CBX5 Protein, Human (His, Myc) is the recombinant human-derived CBX5 protein, expressed by E. coli, with N-10*His & C-Myc tag.
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- Species: Human
- Source: E. coli
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保管条件:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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Technical Parameters
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Product Properties
- ドキュメント
- Help & FAQs
生物活性
製品説明
CBX5 Protein, Human (His, Myc) is the recombinant human-derived CBX5 protein, expressed by E. coli, with N-10*His & C-Myc tag.
Background
CBX5 is a component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. However, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). CBX5 may contribute to the association of heterochromatin with the inner nuclear membrane through interactions with the lamin-B receptor (LBR). Additionally, it is involved in the formation of kinetochores via interaction with the MIS12 complex subunit NSL1 and is required for the formation of the inner centromere.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-10*His;C-Myc
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アクセッション番号
P45973 (M1-S191)
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遺伝子ID23468
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Molecular Construction
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N-term
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10*His
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CBX5 (M1-S191)
Accession # P45973 -
Myc
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C-term
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Protein Length
Full Length
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別名
CBX5; HP1A; Chromobox 5; Chromobox Homolog 5 (Drosophila HP1 Alpha); HP1-ALPHA; Heterochromatin Protein 1-Alpha; HP1alpha; HP1 Alpha Homolog (Drosophila); HP1; Chromobox Homolog 5; Chromobox Homolog 5 (HP1 Alpha Homolog, Drosophila); HP1 Alpha Homolog; He
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AA Sequence
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS
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Predicted Molecular Mass
29.7 kDa
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分子量
Approximately 29.7 kDa,based on SDS-PAGE under reducing conditions.
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純度
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
ドキュメント
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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