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  5. CD105
  6. CD105/Endoglin Protein, Human (HEK293, His-Avi)

CD105/endoglin is a vascular endothelial glycoprotein that plays an important regulatory role in angiogenesis and maintains the structure of the adult vasculature. It controls vascular endothelial cell migration and contributes to extraembryonic angiogenesis and embryonic heart development. CD105/Endoglin Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD105/Endoglin protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

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Descripciòn

CD105/endoglin is a vascular endothelial glycoprotein that plays an important regulatory role in angiogenesis and maintains the structure of the adult vasculature. It controls vascular endothelial cell migration and contributes to extraembryonic angiogenesis and embryonic heart development. CD105/Endoglin Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD105/Endoglin protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
Background

CD105/Endoglin Protein is a vascular endothelium glycoprotein that plays a crucial role in angiogenesis regulation, maintaining the structure and integrity of adult vasculature. It also controls the migration of vascular endothelial cells and contributes to extraembryonic angiogenesis and embryonic heart development. CD105/Endoglin Protein is involved in endothelial cell shape changes in response to blood flow, facilitating vascular remodeling during angiogenesis. Additionally, it acts as a coreceptor for TGF-beta, participating in the TGF-beta/BMP signaling cascade and activating SMAD transcription factors. CD105/Endoglin Protein forms dimers and interacts with various receptors, including TGFBR1, TGFBR2, GDF2, ACVRL1, BMP10, DYNLT4, and ARRB2.
Species

Human
Source

HEK293
Tag

C-Avi;C-8*His
Accession

P17813-1 (E26-G586)
Gene ID
Molecular Construction
N-term
ENG (E26-G586)
Accession # P17813-1
8*His-Avi
C-term
Protein Length

Extracellular Domain
Synonyms
CD105; Endoglin; ENG; ORW; ORW1; END; HHT1
AA Sequence

ETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKG

Predicted Molecular Mass
63.7 kDa
Peso molecular

Approximately 70-82 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Glycosylation
Yes
Pureza

≥ 95%, as determined by Bis-Tris PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentación
Instrucciones de manejo (2659 KB)

CD105/Endoglin Protein, Human (HEK293, His-Avi) Related Classifications

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