CD105/Endoglin Protein, Human (HEK293, His-Avi)
CD105/endoglin is a vascular endothelial glycoprotein that plays an important regulatory role in angiogenesis and maintains the structure of the adult vasculature. It controls vascular endothelial cell migration and contributes to extraembryonic angiogenesis and embryonic heart development. CD105/Endoglin Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD105/Endoglin protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CD105/endoglin is a vascular endothelial glycoprotein that plays an important regulatory role in angiogenesis and maintains the structure of the adult vasculature. It controls vascular endothelial cell migration and contributes to extraembryonic angiogenesis and embryonic heart development. CD105/Endoglin Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD105/Endoglin protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
Background
CD105/Endoglin Protein is a vascular endothelium glycoprotein that plays a crucial role in angiogenesis regulation, maintaining the structure and integrity of adult vasculature. It also controls the migration of vascular endothelial cells and contributes to extraembryonic angiogenesis and embryonic heart development. CD105/Endoglin Protein is involved in endothelial cell shape changes in response to blood flow, facilitating vascular remodeling during angiogenesis. Additionally, it acts as a coreceptor for TGF-beta, participating in the TGF-beta/BMP signaling cascade and activating SMAD transcription factors. CD105/Endoglin Protein forms dimers and interacts with various receptors, including TGFBR1, TGFBR2, GDF2, ACVRL1, BMP10, DYNLT4, and ARRB2.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-Avi;C-8*His
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Accession
P17813-1 (E26-G586)
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Molecular Construction
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N-term
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ENG (E26-G586)
Accession # P17813-1 -
8*His-Avi
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C-term
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Protein Length
Extracellular Domain
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Synonyms
ENG; CD105 Antigen; Prev. ORW1; Endoglin (Osler-Rendu-Weber Syndrome 1); Prev. ORW; Osler-Rendu-Weber Syndrome 1; END; Soluble Endoglin; HHT1; ENG Protein; Endoglin; CD105
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AA Sequence
ETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKG
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Predicted Molecular Mass
63.7 kDa
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Molecular Weight
Approximately 70-82 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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