CD14 Protein, Cynomolgus (HEK293, His)

CD14 protein is a key coreceptor that cooperates with LBP to bind LPS and deliver it to the LY96/TLR4 complex to generate an immune response. CD14 activates NF-kappa-B through MyD88, TIRAP and TRAF6, triggering inflammation and cytokine release. CD14 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD14 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD14 Protein, Cynomolgus (HEK293, His) is 344 a.a., with molecular weight of 44-48 kDa.

CD14 Protein serves as a key coreceptor for bacterial lipopolysaccharide (LPS), collaborating with LBP to bind monomeric LPS and deliver it to the LY96/TLR4 complex, thereby orchestrating the innate immune response. Operating through MyD88, TIRAP, and TRAF6, CD14 activates NF-kappa-B, triggering cytokine release and inflammation. It also functions as a coreceptor for TLR2:TLR6 and TLR2:TLR1 heterodimers in response to diacylated and triacylated lipopeptides, respectively. Additionally, CD14 binds electronegative LDL, mediating cytokine release induced by LDL(-). As a member of the lipopolysaccharide (LPS) receptor complex, which includes CD14, LY96, and TLR4, CD14 interacts with LPAR1, highlighting its versatile roles in immune and signaling pathways.

Cynomolgus

HEK293

C-His

B3Y6B8 (M1-M344)

697482  [NCBI]

44-48 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.