CD42c Protein, Rat (HEK293, Fc)

The CD42c protein is a platelet surface membrane protein that actively assembles plugs by binding to von Willebrand factor (vWF) in the subendothelium. The GP-Ib heterodimer is formed from the disulfide-linked GP-Ib β subunit and one GP-Ib α subunit, which constitute this protein complex. CD42c Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD42c protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD42c Protein, Rat (HEK293, Fc) is 147 a.a., with molecular weight of ~63 kDa.

CD42c, a surface membrane protein on platelets, actively contributes to the assembly of platelet plugs by engaging with von Willebrand factor (vWF), which is pre-bound to the subendothelium. This protein complex comprises two GP-Ib beta subunits disulfide-linked to one GP-Ib alpha subunit, forming the GP-Ib heterodimer. Additionally, GP-IX is intricately associated with the GP-Ib heterodimer through a non-covalent linkage, enhancing the structural integrity and functionality of this platelet surface receptor. In molecular interactions, CD42c shows similarity to its association with tumor necrosis factor receptor-associated factor 4 (TRAF4), contributing to the regulatory network governing platelet function.

Rat

HEK293

C-hFc

Q9JJM7 (M1-C147)

116727  [NCBI]

Approximately 63 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.