CDCP1 Protein, Human (HEK293, Fc)

CDCP1 protein may be involved in cell adhesion and extracellular matrix association. Phosphorylation of CDCP1 may regulate the balance between anchorage and migration, proliferation, and differentiation. CDCP1 Protein, Human (HEK293, Fc) is the recombinant human-derived CDCP1 protein, expressed by HEK293 , with C-hFc labeled tag.

CDCP1 protein is potentially involved in cell adhesion and the association with the extracellular matrix. Its phosphorylation may play a role in regulating the balance between anchorage and migration, as well as proliferation and differentiation. Additionally, CDCP1 has shown promise as a novel marker for leukemia diagnosis and for identifying immature hematopoietic stem cell subsets. It belongs to the tetraspanin web, which is implicated in tumor progression and metastasis. CDCP1 interacts with several proteins including CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4, the serine protease ST14/MT-SP1, as well as SRC and PRKCG/protein kinase C gamma, suggesting its involvement in various cellular processes and signaling pathways.

Human

HEK293

C-hFc

Q9H5V8-1 (F30-L666)

64866  [NCBI]

Extracellular Domain

FEIALPRESNITVLIKLGTPTLLAKPCYIVISKRHITMLSIKSGERIVFTFSCQSPENHFVIEIQKNIDCMSGPCPFGEVQLQPSTSLLPTLNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVTHSISGRIDATVVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANYPEGFPEDELMTWQFVVPAHLRASVSFLNFNLSNCERKEERVEYYIPGSTTNPEVFKLEDKQPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQHPQNESNKIYVVDLSNERAMSLTIEPRPVKQSRKFVPGCFVCLESRTCSSNLTLTSGSKHKISFLCDDLTRLWMNVEKTISCTDHRYCQRKSYSLQVPSDILHLPVELHDFSWKLLVPKDRLSLVLVPAQKLQQHTHEKPCNTSFSYLVASAIPSQDLYFGSFCPGGSIKQIQVKQNISVTLRTFAPSFQQEASRQGLTVSFIPYFKEEGVFTVTPDTKSKVYLRTPNWDRGLPSLTSVSWNISVPRDQVACLTFFKERSGVVCQTGRAFMIIQEQRTRAEEIFSLDEDVLPKPSFHHHSFWVNISNCSPTSGKQLDLLFSVTLTPRTVDL

Approximately 115-130 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Qi X, et al. CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer. Life Sci. 2022 Jul 15;301:120600.  [Content Brief]

  [2]. He Y, et al. CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin. Oncogene. 2020 Jan;39(1):219-233.  [Content Brief]

  [3]. Kajiwara K, et al. CDCP1 promotes compensatory renal growth by integrating Src and Met signaling. Life Sci Alliance. 2021 Feb 11;4(4):e202000832.  [Content Brief]

  [4]. Conze T, et al. CDCP1 is a novel marker for hematopoietic stem cells. Ann N Y Acad Sci. 2003 May;996:222-6.  [Content Brief]

  [5]. Scherl-Mostageer M, et al. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene. 2001 Jul 19;20(32):4402-8.  [Content Brief]