CEACAM5 Protein, Mouse (HEK293, Fc)

The CEACAM5 protein is a key cell surface glycoprotein that promotes cell adhesion, signaling, and tumor progression. It interacts with CEACAM6 and other related molecules to support homo- and hetero-sex adhesion. CEACAM5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CEACAM5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CEACAM5 Protein, Mouse (HEK293, Fc) is 913 a.a., with molecular weight of 135-180 kDa.

The CEACAM5 protein, a cell surface glycoprotein, assumes a pivotal role in cell adhesion, intracellular signaling, and tumor progression. It facilitates both homophilic and heterophilic cell adhesion, engaging with other carcinoembryonic antigen-related cell adhesion molecules, notably CEACAM6. Functioning as an oncogene, CEACAM5 contributes to tumor progression by inducing resistance to anoikis in colorectal carcinoma cells. This glycoprotein forms homodimers, emphasizing its role as a multifaceted regulator in cellular interactions and signaling pathways, particularly influencing processes associated with cancer development and progression.

Mouse

HEK293

C-hFc

Q3UKK2 (Q35-E947)

73250  [NCBI]

Full Length of Mature Protein (with Propeptide)

QITIELEPPQVIEGENVLIRVNNLTENLITLAWFRGMRIKSPQIGQYTPATKVTVLGPGHSGRETLYSNGSLQIYNVTQEDIGFYSLRIINKHAEIVSITSIYLNVYSSLWTCEHPSPHAKLTIESVPPGISEGGSVLLLVKNLPQNLLSLFWYKGVIAVKKFEIARHIKATNSSVPGPAHTGRETVFSNGSLLLQEVMQSDTGFYTLRTMSTDLKDEVAHVQLYMDTYLLTCYHPLQVKIESLPQNVAVGKTVLLLVHNLPEDFQAFFWYKSAYRRDTYKIAEYKRAMDATILGSAYSSREFIYNNGSMLIIDVTEDDAGYFLLEILREDLKIEKAYIQLHVNSFVSNSKDSASTARLSIESVPPSIVEGGSVLLLVHNLPKNLQSLFWYKGMIAEKKSELIQHIIATSSSLPGPAHSGRETVYNNGSLLLQRVMQNDTQFYTLQTMDTDLKYEVAHVQLQLDTSLSTWYHPLQVKIESLPRNVAVGKSVLFLVHNFPEVFRAFSWYKPAYKSHTSKIVEYHRFTDSATVGAAYRGIEVIFTNGSMVMIDVTEDDAGFYMLEILREDFKVEKAYVQLHVNSFVPNSKVSVSTARLSIESVPPSIVGGESVLLLVHNLPKNLQSLFWYKGVIAEEKSELIQHIIATSSSLPGPAHSGRETVYSNGSLLLQRVMQNDTGFYTLLTMSTDLKDEIAHVQLQLDTSTCCSLLTSDQLIIVPVPRNIAVGKSVLLLVCNVPKDVQTIFWYKSVYRTDIFKIAEYSRSMESTIWGLAHSGKEMVYTNGSLLIQNVTEHDAGLYMLEILHKDYKLERAHVQVHVNNPVSWPFVRVTDTTVRVQSSVVFTCFSADPGVSIRWLFNKQSLQLTERMTLSPSKCQLSIDPVWREDAGKYQCEVSNPVSSKSSLPVRLAVIEE

135-180 kDa

≥ 90%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized a 0.22 μm filtered solution of 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5. Normally trehalose is added as protectant before lyophilization.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.