GM-CSF Protein, Human (P.pastoris, N-His)
The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GM-CSF Protein, Human (P.pastoris, N-His) is the recombinant human-derived GM-CSF protein, expressed by P. pastoris , with N-6*His labeled tag.
- Species: Human
- Source: P. pastoris
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GM-CSF Protein, Human (P.pastoris, N-His) is the recombinant human-derived GM-CSF protein, expressed by P. pastoris , with N-6*His labeled tag.
Background
GMP GM-CSF Protein functions as a pivotal cytokine, fostering the growth and differentiation of hematopoietic precursor cells spanning diverse lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GMP GM-CSF serves as a signaling molecule, orchestrating a complex receptor assembly. This receptor complex takes the shape of a dodecamer, consisting of two head-to-head hexamers, each composed of two alpha, two beta, and two ligand subunits. This structural intricacy underscores the specificity and regulatory role of GMP GM-CSF in directing cellular responses within the hematopoietic system.
Technical Parameters
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Species Human
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Source P. pastoris
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Tag N-6*His
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Accession
P04141 (A18-E144)
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Molecular Construction
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N-term
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6*His
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GM-CSF (A18-E144)
Accession # P04141 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
CSF2; Molgramostim; Colony Stimulating Factor 2; Molgramostin; GMCSF; CSF; Sargramostim; Granulocyte-Macrophage Colony Stimulating Factor; GM-CSF; Granulocyte Macrophage-Colony Stimulating Factor; Colony Stimulating Factor 2 (Granulocyte-Macrophage); Colo
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AA Sequence
APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
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Predicted Molecular Mass
17.1 kDa
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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