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  6. EDAR Protein, Rat (HEK293, Fc)

EDAR Protein, Rat (HEK293, Fc)

Cat. No.: HY-P75261
Handling Instructions

EDAR Protein is a typical Tumor Necrosis Factor receptor (TNFR) family member. EDAR is a receptor for EDA isoform A1. Its binding results in recruitment of the intracellular EDAR-associated death domain (EDARADD) adapter protein and simultaneous activation of NF-kappa-B and JNK signaling pathways, potentially leading to various cellular responses. Additionally, EDAR may play a role in promoting caspase-independent cell death. EDAR Protein, Rat (HEK293, Fc) is the recombinant rat-derived EDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDAR Protein, Rat (HEK293, Fc) is 161 a.a., with molecular weight of 60-70 kDa.

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Description

EDAR Protein is a typical Tumor Necrosis Factor receptor (TNFR) family member. EDAR is a receptor for EDA isoform A1. Its binding results in recruitment of the intracellular EDAR-associated death domain (EDARADD) adapter protein and simultaneous activation of NF-kappa-B and JNK signaling pathways, potentially leading to various cellular responses. Additionally, EDAR may play a role in promoting caspase-independent cell death. EDAR Protein, Rat (HEK293, Fc) is the recombinant rat-derived EDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDAR Protein, Rat (HEK293, Fc) is 161 a.a., with molecular weight of 60-70 kDa.

Background

Ectodysplasin-A receptor (EDAR) is a typical Tumor Necrosis Factor receptor (TNFR) family member. EDAR is a receptor specifically for EDA isoform A1, distinguishing it from EDA isoform A2. EDA-A1/EDAR binding results in recruitment of the intracellular EDAR-associated death domain (EDARADD) adapter protein and simultaneous activation of NF-kappa-B and JNK signaling pathways, potentially leading to various cellular responses. Additionally, EDAR may play a role in promoting caspase-independent cell death. The receptor forms a complex with EDARADD, and it is associated with key signaling molecules such as TRAF1, TRAF2, TRAF3, and NIK, indicating its involvement in intricate signaling cascades. Furthermore, EDAR promots tumor cell proliferation by inducing Wnt/β-catenin signaling[1].

Species

Rat

Source

HEK293

Tag

C-hFc

Accession

D3ZGP2/NP_001178828.1 (E27-A187)

Gene ID

365581  [NCBI]

Molecular Construction
N-term
EDAR (E27-A187)
Accession # D3ZGP2/NP_001178828.1
hFc
C-term
Synonyms
Tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; EDAR
Molecular Weight

60-70 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

EDAR Protein, Rat (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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EDAR Protein, Rat (HEK293, Fc)
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HY-P75261
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