FGFRL1 Protein, Human (HEK293, His)
The FGFRL1 protein negatively affects cell proliferation, revealing its role as a potential regulator during cell growth. In addition, it interacts with FGF2, showing significant but low affinity for this fibroblast growth factor. FGFRL1 Protein, Human (HEK293, His) is the recombinant human-derived FGFRL1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The FGFRL1 protein negatively affects cell proliferation, revealing its role as a potential regulator during cell growth. In addition, it interacts with FGF2, showing significant but low affinity for this fibroblast growth factor. FGFRL1 Protein, Human (HEK293, His) is the recombinant human-derived FGFRL1 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
FGFRL1 (Fibroblast Growth Factor Receptor-Like 1) is a protein known for its negative regulatory effect on cell proliferation. Unlike typical fibroblast growth factor receptors, FGFRL1 exhibits low-affinity interactions with FGF2, a member of the fibroblast growth factor family. This distinct binding characteristic suggests a unique role for FGFRL1 in modulating cellular responses to FGF signaling, potentially influencing cell growth and differentiation. The negative impact on cell proliferation implicates FGFRL1 as a regulatory component in cellular processes, and its interaction with FGF2 highlights its potential involvement in fine-tuning FGF-mediated signaling pathways.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
Q8N441 (A25-P378)
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Molecular Construction
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N-term
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FGFRL1 (A25-P378)
Accession # Q8N441 -
6*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
FGFRL1; FGF Receptor-Like Protein 1; Fibroblast Growth Factor Receptor Like 1; FGFR-Like Protein; FGFR5; FGFR-5; Fibroblast Growth Factor Receptor 5; FHFR; Fibroblast Growth Factor Receptor-Like 1; FGFRL1 Protein; FGF Homologous Factor Receptor
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AA Sequence
ARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWP
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Predicted Molecular Mass
39.9 kDa
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Molecular Weight
Approximately 65 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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