GLUD1 Protein, Human
Based on 1 Customer Validation
GLUD1 protein is a mitochondrial glutamate dehydrogenase that converts L-glutamate into α-ketoglutarate, supporting glutamine anaplerosis and the tricarboxylic acid cycle. In addition to metabolism, GLUD1 plays a key role in insulin homeostasis, complexly regulating glucose metabolism. GLUD1 Protein, Human is the recombinant human-derived GLUD1 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
GLUD1 protein is a mitochondrial glutamate dehydrogenase that converts L-glutamate into α-ketoglutarate, supporting glutamine anaplerosis and the tricarboxylic acid cycle. In addition to metabolism, GLUD1 plays a key role in insulin homeostasis, complexly regulating glucose metabolism. GLUD1 Protein, Human is the recombinant human-derived GLUD1 protein, expressed by E. coli , with tag free.
GLUD1 protein, a mitochondrial glutamate dehydrogenase, stands as a critical catalyst in the conversion of L-glutamate to alpha-ketoglutarate, thereby playing a pivotal role in glutamine anaplerosis and supplying the tricarboxylic acid cycle with a crucial intermediate. Beyond its metabolic functions, GLUD1 emerges as a key player in insulin homeostasis, contributing to the intricate regulation of glucose metabolism. Additionally, there is suggestive evidence implicating GLUD1 in cognitive processes, hinting at its potential involvement in learning and memory reactions through modulation of the excitatory neurotransmitter glutamate turnover.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P00367 (S54-T558)
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Gene ID2746
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Molecular Construction
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N-term
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GLUD1 (S54-T558)
Accession # P00367 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
GLUD1; GDH; Prev. GLUD; Epididymis Tissue Sperm Binding Protein Li 18mP; Glutamate Dehydrogenase 1, Mitochondrial; Epididymis Secretory Sperm Binding Protein; HGDH1; Glutamate Dehydrogenase; GDH1; GDH 1; Glutamate Dehydrogenase 1; Glutamate Dehydrogenase
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AA Sequence
SEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
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Predicted Molecular Mass
56.0 kDa
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Molecular Weight
Approximately 56 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 50 mM HEPES, pH 7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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