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  5. glycoprotein/G Protein, HRSV (HEK293, His)

glycoprotein/G Protein, HRSV (HEK293, His)

Cat. No.: HY-P74124
Handling Instructions

The glycoprotein/G protein plays a pivotal role in infection by attaching the virion to the host cell membrane through heparan sulfate interaction, initiating infection. It also interacts with host CX3CR1, the receptor for CX3C chemokine fractalkine, contributing to immune modulation and facilitating infection. Distinguished by lacking neuraminidase and hemagglutinating activities, the glycoprotein enables the virus to evade antibody-dependent replication restriction, acting as an antigen decoy and modulating Fc-gamma receptor-carrying leukocyte activity. glycoprotein/G Protein, HRSV (HEK293, His) is the recombinant Virus-derived glycoprotein/G protein, expressed by HEK293, with C-His labeled tag. The total length of glycoprotein/G Protein, HRSV (HEK293, His) is 233 a.a., with molecular weight of 80-90 kDa.

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Description

The glycoprotein/G protein plays a pivotal role in infection by attaching the virion to the host cell membrane through heparan sulfate interaction, initiating infection. It also interacts with host CX3CR1, the receptor for CX3C chemokine fractalkine, contributing to immune modulation and facilitating infection. Distinguished by lacking neuraminidase and hemagglutinating activities, the glycoprotein enables the virus to evade antibody-dependent replication restriction, acting as an antigen decoy and modulating Fc-gamma receptor-carrying leukocyte activity. glycoprotein/G Protein, HRSV (HEK293, His) is the recombinant Virus-derived glycoprotein/G protein, expressed by HEK293, with C-His labeled tag. The total length of glycoprotein/G Protein, HRSV (HEK293, His) is 233 a.a., with molecular weight of 80-90 kDa.

Background

The glycoprotein/G protein plays a pivotal role in infection by attaching the virion to the host cell membrane through interaction with heparan sulfate, initiating the infection. Additionally, it interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune modulation and facilitating infection. Distinguished from other paramyxovirus attachment proteins, the glycoprotein lacks both neuraminidase and hemagglutinating activities. Its unique features enable the virus to evade antibody-dependent restriction of replication by functioning as an antigen decoy and modulating the activity of leukocytes carrying Fc-gamma receptors.

Species

Virus

Source

HEK293

Tag

C-His

Accession

O36633 (H67-A299)

Gene ID

1489824  [NCBI]

Molecular Construction
N-term
HRSV G (H67-A299)
Accession # O36633
His
C-term
Synonyms
Major surface glycoprotein G; mG; Mature sG; G
Molecular Weight

80-90 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

glycoprotein/G Protein, HRSV (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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glycoprotein/G Protein, HRSV (HEK293, His)
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HY-P74124
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