glycoprotein/G Protein, HRSV (HEK293, His)
Glycoproteins/G proteins play a key role in infection by attaching viral particles to the host cell membrane through heparan sulfate interactions, thereby initiating infection. It also interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune regulation and promoting infection. glycoprotein/G Protein, HRSV (HEK293, His) is the recombinant Virus-derived glycoprotein/G protein, expressed by HEK293 , with C-His labeled tag.
- Species: Virus
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Glycoproteins/G proteins play a key role in infection by attaching viral particles to the host cell membrane through heparan sulfate interactions, thereby initiating infection. It also interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune regulation and promoting infection. glycoprotein/G Protein, HRSV (HEK293, His) is the recombinant Virus-derived glycoprotein/G protein, expressed by HEK293 , with C-His labeled tag.
Background
The glycoprotein/G protein plays a pivotal role in infection by attaching the virion to the host cell membrane through interaction with heparan sulfate, initiating the infection. Additionally, it interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune modulation and facilitating infection. Distinguished from other paramyxovirus attachment proteins, the glycoprotein lacks both neuraminidase and hemagglutinating activities. Its unique features enable the virus to evade antibody-dependent restriction of replication by functioning as an antigen decoy and modulating the activity of leukocytes carrying Fc-gamma receptors.
Technical Parameters
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Species Virus
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Source HEK293
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Tag C-His
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Accession
O36633-1 (H67-A299)
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Gene ID1489824 [NCBI]
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Molecular Construction
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N-term
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HRSV G (H67-A299)
Accession # O36633-1 -
His
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C-term
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Protein Length
Full Length of Mature secreted glycoprotein G Chain
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Synonyms
Major surface glycoprotein G; Attachment glycoprotein G; Membrane-bound glycoprotein; mG; Mature secreted glycoprotein G; Mature secreted glycoprotein G; Mature secreted glycoprotein G; G
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AA Sequence
HKVTLTTVTVQTIKNHTEKNITTYLTQVPPERVSSSKQPTTTSPIHTNSATTSPNTKSETHHTTAQTKGRTTTSTQTNKPSTKPRLKNPPKKPKDDYHFEVFNFVPCSICGNNQLCKSICKTIPSNKPKKKPTIKPTNKPTTKTTNKRDPKTPAKTTKKETTTNPTKKPTLTTTERDTSTSQSTVLDTTTLEHTIQQQSLHSTTPENTPNSTQTPTASEPSTSNSTQNTQSHA
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Predicted Molecular Mass
27 kDa
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Molecular Weight
Approximately 80-90 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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