HEPACAM2 Protein, Rat (HEK293, Fc)

The HEPACAM2 gene encodes a protein associated with an immunoglobulin superfamily that plays a role in mitosis. Knocking down this gene can lead to prophase cell arrest, abnormal nuclear morphology and apoptosis. HEPACAM2 can be used as a biomarker for the prognosis of colorectal adenocarcinoma. HEPACAM2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HEPACAM2 protein, expressed by HEK293 , with C-hFc labeled tag.

HepaCAM, an N-linked glycoprotein encoding a member of the immunoglobulin superfamily, is a tumor suppressor gene that mediates multiple cellular biological functions. HepaCAM may be a novel therapeutic target for inhibiting bladder cancer proliferation through the AKT/FoxO pathway. The HEPACAM2 gene encodes a protein associated with an immunoglobulin superfamily that plays a role in mitosis. Knocking down this gene can lead to prophase cell arrest, abnormal nuclear morphology and apoptosis. The polymerization (ADP-ribosylation) of the encoding protein promotes its translocation to the centrosome, which may stimulate centrosome maturation. Deletion of chromosomes containing this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. HEPACAM2 can be used as a biomarker for the prognosis of colorectal adenocarcinoma^[1][2][3].

Rat

HEK293

C-hFc

B5DEN8 (L33-L350)

296846  [NCBI]

Partial

LKVTVPSHTVHGIRGQALYLPVHYGFHTPASDIQIIWLFERSHTTPKYLLGSVNKSVVPDLEYQHKFTMMPPNASLLINPLQFTDEGNYIVKVNIQGNGTLSASQKIQVTVDDPVMKPMVQFHPASGAVEYVGNITLTCRVEGGTRLVYQWRKNGKPININSSHSFSPQNHTLRIVPATKEDIGNYTCLVSNPVSEMESDIIIPTIYYGPYGLQVNSDKGLKVGEVFTVDLGEAVLFDCSADSYPPNTYSWIRRSANTTRVIKHGPRLEVASDKVAQKTADYVCCAYNNITGRRDETHFTVIITSVGLEKLAQRGKSL

Approximately 66-73 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.