HEPACAM2 Protein, Rat (HEK293, Fc)
The HEPACAM2 gene encodes a protein associated with an immunoglobulin superfamily that plays a role in mitosis. Knocking down this gene can lead to prophase cell arrest, abnormal nuclear morphology and apoptosis. HEPACAM2 can be used as a biomarker for the prognosis of colorectal adenocarcinoma. HEPACAM2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HEPACAM2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Species: Rat
- Source: HEK293
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The HEPACAM2 gene encodes a protein associated with an immunoglobulin superfamily that plays a role in mitosis. Knocking down this gene can lead to prophase cell arrest, abnormal nuclear morphology and apoptosis. HEPACAM2 can be used as a biomarker for the prognosis of colorectal adenocarcinoma. HEPACAM2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HEPACAM2 protein, expressed by HEK293 , with C-hFc labeled tag.
Background
HepaCAM, an N-linked glycoprotein encoding a member of the immunoglobulin superfamily, is a tumor suppressor gene that mediates multiple cellular biological functions. HepaCAM may be a novel therapeutic target for inhibiting bladder cancer proliferation through the AKT/FoxO pathway. The HEPACAM2 gene encodes a protein associated with an immunoglobulin superfamily that plays a role in mitosis. Knocking down this gene can lead to prophase cell arrest, abnormal nuclear morphology and apoptosis. The polymerization (ADP-ribosylation) of the encoding protein promotes its translocation to the centrosome, which may stimulate centrosome maturation. Deletion of chromosomes containing this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. HEPACAM2 can be used as a biomarker for the prognosis of colorectal adenocarcinoma[1][2][3].
Technical Parameters
-
Species Rat
-
Source HEK293
-
Tag C-hFc
-
Accession
B5DEN8 (L33-L350)
-
Molecular Construction
-
N-term
-
HEPACAM2 (L33-L350)
Accession # B5DEN8 -
hFc
-
C-term
-
-
Protein Length
Partial
-
Synonyms
HEPACAM2; FLJ38683; HEPACAM Family Member 2; MIKI; Mitotic Kinetics Regulator; Alternative Protein HEPACAM2
-
AA Sequence
LKVTVPSHTVHGIRGQALYLPVHYGFHTPASDIQIIWLFERSHTTPKYLLGSVNKSVVPDLEYQHKFTMMPPNASLLINPLQFTDEGNYIVKVNIQGNGTLSASQKIQVTVDDPVMKPMVQFHPASGAVEYVGNITLTCRVEGGTRLVYQWRKNGKPININSSHSFSPQNHTLRIVPATKEDIGNYTCLVSNPVSEMESDIIIPTIYYGPYGLQVNSDKGLKVGEVFTVDLGEAVLFDCSADSYPPNTYSWIRRSANTTRVIKHGPRLEVASDKVAQKTADYVCCAYNNITGRRDETHFTVIITSVGLEKLAQRGKSL
-
Predicted Molecular Mass
62.3 kDa
-
Molecular Weight
Approximately 66-73 kDa, based on SDS-PAGE under reducing conditions.
-
Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
