HTRA3 Protein, Human (His)

HTRA3 Protein, Human (His) is the recombinant human-derived HTRA3, expressed by E. coli , with His labeled tag. ,

HTRA3 is a serine protease that cleaves beta-casein/CSN2 and several extracellular matrix (ECM) proteoglycans, including decorin/DCN, biglycan/BGN, and fibronectin/FN1. It potentially inhibits signaling mediated by TGF-beta family proteins, likely indirectly through the degradation of these ECM proteoglycans (by similarity). This protein may function as a tumor suppressor. In vitro studies suggest it negatively regulates trophoblast invasion during placental development, with possible in vivo relevance. Additionally, HTRA3 might play roles in ovarian development, granulosa cell differentiation, and luteinization.

Human

E. coli

His

P83110-1 (Q132-K353)

94031

Partial

QLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWK

≥ 90%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 50mM Tris-HCl, pH 8.0, 300mM NaCl, 150mM imidazole and 10% glycerol.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.