HTRA3 Protein, Human (His)
HTRA3 Protein, Human (His) is the recombinant human-derived HTRA3, expressed by E. coli , with His labeled tag. ,
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
HTRA3 Protein, Human (His) is the recombinant human-derived HTRA3, expressed by E. coli , with His labeled tag. ,
HTRA3 is a serine protease that cleaves beta-casein/CSN2 and several extracellular matrix (ECM) proteoglycans, including decorin/DCN, biglycan/BGN, and fibronectin/FN1. It potentially inhibits signaling mediated by TGF-beta family proteins, likely indirectly through the degradation of these ECM proteoglycans (by similarity). This protein may function as a tumor suppressor. In vitro studies suggest it negatively regulates trophoblast invasion during placental development, with possible in vivo relevance. Additionally, HTRA3 might play roles in ovarian development, granulosa cell differentiation, and luteinization.
Technical Parameters
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Species Human
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Source E. coli
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Tag His
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Accession
P83110-1 (Q132-K353)
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Gene ID94031
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Protein Length
Partial
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Synonyms
HTRA3; High-Temperature Requirement Factor A3; HtrA Serine Peptidase 3; Serine Protease HTRA3; Pregnancy-Related Serine Protease; Probable Serine Protease HTRA3; Tasp; PRSP; Prsp
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AA Sequence
QLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWK
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Molecular Weight
Approximately 27 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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