IGFBP-5 Protein, Human (Biotinylated, HEK293, Avi-Flag, His)
The IGFBP-5 protein regulates insulin-like growth factor (IGF) and extends its lifespan. It can inhibit or stimulate the growth-promoting effect of IGF, showing its dual regulatory function. IGFBP-5, Human (Biotinylated, HEK293, Avi-Flag, His) is the recombinant human-derived IGFBP-5 protein, expressed by HEK293, with C-Avi;C-hFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The IGFBP-5 protein regulates insulin-like growth factor (IGF) and extends its lifespan. It can inhibit or stimulate the growth-promoting effect of IGF, showing its dual regulatory function. IGFBP-5, Human (Biotinylated, HEK293, Avi-Flag, His) is the recombinant human-derived IGFBP-5 protein, expressed by HEK293, with C-Avi;C-hFc labeled tag.
Background
IGFBP-5 protein assumes a crucial role in regulating the activity of insulin-like growth factors (IGFs) by extending their half-life. Within cell culture, IGFBP-5 has demonstrated the ability to either inhibit or stimulate the growth-promoting effects of IGFs. This dual regulatory function underscores the complexity of IGFBP-5's influence on cellular processes. Importantly, IGFBP-5 achieves these effects by modulating the interaction between IGFs and their cell surface receptors, thereby fine-tuning the signaling pathways associated with growth and development. The intricate interplay between IGFBP-5 and IGFs highlights the nuanced control mechanisms that govern cellular responses to growth factors, offering insights into the multifaceted role of IGFBP-5 in the regulation of cellular growth and proliferation.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-Avi;C-His;N-Flag
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Accession
P24593 (L21-E272)
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Gene ID3488
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Molecular Construction
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N-term
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Flag-Avi
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IGFBP-5 (L21-E272)
Accession # P24593 -
His
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C-term
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Protein Length
Full Length of Mature Protein
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Conjugation
Biotin
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Synonyms
IGFBP5; IBP-5; Insulin Like Growth Factor Binding Protein 5; IBP5; Insulin-Like Growth Factor-Binding Protein 5; Insulin-Like Growth Factor Binding Protein 5; IGF-Binding Protein 5; IGFBP5 Protein; IGFBP-5
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AA Sequence
LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
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Predicted Molecular Mass
33.3 kDa
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Molecular Weight
Approximately 38-43 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
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It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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