IL-16 Protein, Human (His)

IL-16 Protein, a cytokine, regulates immunity and inflammation. It controls the activation and movement of immune cells like T cells and monocytes. Understanding IL-16 Protein's functions helps study immune responses and develop treatments for inflammatory and autoimmune disorders. IL-16 Protein, Human (His) is the recombinant human-derived IL-16 protein, expressed by E. coli , with N-His labeled tag.

IL-16, a multifunctional cytokine, elicits a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Additionally, it primes CD4+ T-cells for responsiveness to IL-2 and IL-15, and induces the expression of interleukin-2 receptor in T-lymphocytes. Functioning as a ligand for CD4, IL-16 plays a key role in cellular interactions and immune modulation. Beyond its immunomodulatory functions, IL-16 may serve as a scaffolding protein that anchors ion channels in the cell membrane, contributing to its diverse cellular effects.

Human

E. coli

N-His

AAC12732.1 (P2-S130)

3603  [NCBI]

Full Length of Mature Protein

PDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS

Approximately 24 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.