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  3. Hydrolases (EC 3)
  4. JOSD2 Protein, Human

JOSD2 Protein, Human

Cat. No.: HY-P701476
Handling Instructions

The JOSD2 protein serves as an enzymatic entity capable of cleaving "Lys-63"-linked polyubiquitin chains and, to a lesser extent, "Lys-48"-linked polyubiquitin chains in vitro. This suggests its potential role as a deubiquitinating enzyme involved in the removal of specific ubiquitin linkages. JOSD2 Protein, Human is the recombinant human-derived JOSD2 protein, expressed by E. coli , with tag free. The total length of JOSD2 Protein, Human is 187 a.a., .

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

The JOSD2 protein serves as an enzymatic entity capable of cleaving "Lys-63"-linked polyubiquitin chains and, to a lesser extent, "Lys-48"-linked polyubiquitin chains in vitro. This suggests its potential role as a deubiquitinating enzyme involved in the removal of specific ubiquitin linkages. JOSD2 Protein, Human is the recombinant human-derived JOSD2 protein, expressed by E. coli , with tag free. The total length of JOSD2 Protein, Human is 187 a.a., .

Background

JOSD2 (Josephin-2) protein functions as a deubiquitinating enzyme, exhibiting cleavage activity on 'Lys-63'-linked poly-ubiquitin chains with high efficiency and, to a lesser extent, on 'Lys-48'-linked poly-ubiquitin chains in vitro. The enzyme's ability to specifically target and cleave these distinct poly-ubiquitin linkages suggests its involvement in regulating various cellular processes, including protein degradation and signaling pathways mediated by ubiquitination. While further research is needed to elucidate its specific physiological roles, the identified deubiquitinating activity positions JOSD2 as a potential key player in modulating ubiquitin-dependent cellular mechanisms (

Species

Human

Source

E. coli

Tag

Tag Free

Accession

Q8TAC2 (S2-D188)

Gene ID

126119

Molecular Construction
N-term
JOSD2 (S2-D188)
Accession # Q8TAC2
C-term
Synonyms
JOSD2; Josephin-2; Josephin domain-containing protein 2
Purity

Greater than 80% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

JOSD2 Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
JOSD2 Protein, Human
Cat. No.:
HY-P701476
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