KLRG1 Protein, Mouse (HEK293, Fc)

KLRG1 Protein plays a pivotal role in inhibiting NK cells and T-cell functions by binding to non-MHC ligands. It engages in missing self-recognition, monitoring the expression of classical cadherins like E-cadherin/CDH1. Existing as a monomer or homodimer, KLRG1 employs its ITIM to interact with PTPN11 and INPP5D, modulating cellular responses and contributing to immune regulation. KLRG1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived KLRG1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of KLRG1 Protein, Mouse (HEK293, Fc) is 132 a.a., with molecular weight of 43-50 kDa.

KLRG1 Protein assumes a pivotal role in exerting inhibitory effects on both natural killer (NK) cells and T-cell functions through its binding to non-MHC ligands. By engaging in missing self-recognition, KLRG1 monitors the expression of classical cadherins, including E-cadherin/CDH1, N-cadherin/CDH2, and R-cadherin/CDH4 on target cells. Existing as both a monomer and homodimer with disulfide linkage, KLRG1 employs its immunoreceptor tyrosine-based inhibitory motif (ITIM) to interact with signaling molecules such as PTPN11 and INPP5D, thereby modulating cellular responses and contributing to immune regulation.

Mouse

HEK293

N-hFc

O88713 (Q57-Y188)

50928  [NCBI]

43-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.