NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi)

NPR1 Protein, a receptor for atrial natriuretic peptide NPPA/ANP and brain natriuretic peptide NPPB/BNP, initiates signaling cascades with guanylate cyclase activity upon ligand binding. Essential vasoactive hormones, these peptides regulate cardiovascular homeostasis. NPR1 significantly contributes to vascular tone and fluid balance regulation in the cardiovascular system through its role as a receptor for these natriuretic peptides. NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived NPR1/NPRA protein, expressed by HEK293, with C-His and C-Avi labeled tag.

The NPR1 Protein serves as a receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP, essential vasoactive hormones that play a pivotal role in cardiovascular homeostasis. Upon binding to these ligands, NPR1 exhibits guanylate cyclase activity, initiating signaling cascades crucial for maintaining cardiovascular balance. Through its role as a receptor for these natriuretic peptides, NPR1 contributes significantly to the regulation of vascular tone and fluid balance in the cardiovascular system.

Human

HEK293

C-Avi;C-8*His

P16066 (G33-E473)

4481

Extracellular Domain

Biotin

The single lysine residue in Avitag is biotinylated through an enzymatic reaction.

GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLE

Approximately 65-80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

<1 EU/μg, determined by LAL method.